In the hundred years spanning the millennium (1935-2035), a disparate bunch of heroes and villains battle against their own challenges. Although each is unaware of the others, they all share an ageless common spirit of adventure, but unknown to them their daring actions have attracted the attention of the TimeSplitters.

The TimeSplitters are an evil race dwelling outside of time and space. For aeons they have manipulated the fate of humanity for their own malign ends, with cursed shards of crystal they have sown fear, greed and conflict throughout history. Now roused from an ancient sleep, the TimeSplitters cross the threshold from their shadowy dimension, ripping through the fabric of time itself to confront our heroes. Can our heroes unite against a common enemy to realise a greater destiny? Or will humanity be consigned forever to a realm ruled under the shadow of the TimeSplitters?